منابع مشابه
Phosphate and FGF-23
Fibroblast growth factor (FGF)-23 is probably the most important regulator of serum phosphate and calcitriol (1,25(OH)₂D₃) levels. It is secreted by osteocytes and osteoblasts in response to oral phosphate loading or increased serum 1,25(OH)₂D₃ levels. In human chronic kidney disease (CKD), plasma FGF-23 appears to be a sensitive biomarker of abnormal renal phosphate handling, as FGF-23 levels ...
متن کاملClinical significance of FGF-23 in Chronic Kidney Disease Patients
Fibroblast growth factor 23 (FGF-23) is a potent regulator of serum phosphate level. In CKD, circulating FGF-23 levels gradually increase with declining renal function. Higher FGF-23 level was associated with higher atherosclerosis score. We aimed to study the correlation between FGF-23 and the parameters that have effects on morbidity and mortality in CKD patients and to establish its role as ...
متن کاملFGF-23 and Left Ventricular Hypertrophy
Submit Manuscript | http://medcraveonline.com cardiovascular health [1]. Among these FGFs, notably FGF-21 has shown cardio-protective effects such as improving lipoprotein profile, endothelial dysfunction and reducing plaque formation [1]. FGF-23; member of the FGF19 subfamily shows the highest degree of homology with FGF-21 [2,3]. However, contrary to FGF21, elevated levels of the bone-derived...
متن کاملPTH, FGF-23 and early CKD.
Patients with early CKD (GFR > 30 ml/min per 1.73 m2) do not usually have changes in the serum calcium and phosphate concentration. PTH may be minimally increased and more recent publications have shown that the phosphaturic hormone, FGF-23, is clearly increased. Thus in early CKD, serum levels of phosphate and calcium are maintained within normal levels because hormonal changes compensate for ...
متن کاملFGF-23 and future cardiovascular events in patients with chronic kidney disease before initiation of dialysis treatment.
BACKGROUND High levels of the phosphaturic hormone fibroblast growth factor 23 (FGF-23) predict mortality in haemodialysis patients. The prognostic relevance of increased plasma FGF-23 levels in patients with less advanced chronic kidney disease (CKD) who are not on dialysis therapy is presently unknown. METHODS We measured plasma c-terminal FGF-23 levels in 149 CKD patients not undergoing di...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Current Opinion in Endocrinology & Diabetes and Obesity
سال: 2016
ISSN: 1752-296X
DOI: 10.1097/med.0000000000000294